ATEM Structural Discovery

ATEM’s vision is to provide our pharmaceutical and biotechnological clients with unprecedented empirical insights into protein structures for successful and accelerated rational drug discovery campaigns. ATEM’s specialised expertise delivers high-resolution cryo electron microscopy (cryo EM) 3D structures of your challenging biological targets. We achieve this by leveraging our unique, completely integrated platform that combines cryo EM optimised biochemical processes with high-end data acquisition hardware and data processing augmented by continuous machine-learning enhancements. Utilising next-gen proprietary software, ATEM delivers more detailed, high-resolution 3D structural models with best-in-class accuracy and faster turnaround times. High-resolution 3D Structural models | Highest accuracy | Faster turnaround times The ATEM cryo EM platform provides unprecedented 3D solutions: * High-resolution 3D structures of difficult to crystallise targets such as large assemblies and membrane proteins * 3D atomic models of ligand-bound targets that allow for extended ligand screening campaigns * Structure determination of high-affinity protein-protein interactions (such as monoclonal antibodies or peptides) * Functional dynamic 3D structural models of the target molecule induced by ligand interactions (small-molecule or biological) * 3D epitope mapping of your target with a palette of mAb/Fab candidates ATEM also provides Analytical EM capabilities: * Rapid transmission electron microscopy (TEM) based insights on protein purification optimisation * Viral vector (i.e. AAV) fill rate analysis with single-particle precision * Morphological characterisations of Lipid Nanoparticle vector systems (i.e. mRNA vaccines) Learn how ATEM can tailor a solution to accelerate your next drug discovery campaign. To find out more about ATEM, visit our website at: www.atem.bio