XDemics Corporation

XDemics, a Caltech spinout, is fundamentally improving the way cells are grown. We’ve addressed a primary bottleneck—the basic inability to efficiently transfer oxygen in media during cell growth. Our high-density cell respiration (HDCR) technology enables mammalian cells to grow at 20- to 100-fold higher densities—whether in a Petri dish or a large-scale bioreactor. As a result, scientists and manufacturers can produce more high-quality, viable cells in far less space and time, dramatically slashing R&D and manufacturing costs. From the lab bench to industrial-scale production, HDCR is transformative. One Expansify™ Petri dish replaces 25 traditional polystyrene dishes, vastly accelerating biomedical innovation while cutting costs. With predictable process scale-up, our Profusion-Midi™ 5L and Profusion-Max™ 50L bioreactors can respectively generate up to 1–10 trillion cells, eliminating the need for massive, complicated 200–2000L stirred-tank vessels. HDCR systems deliver high-quality cell and gene therapies more efficiently, reducing the overall cost of these advanced medicines by up to 80%, achieving cost parity with biologics and making these life-changing treatments more accessible worldwide. Our laboratory facilities are located on the beautiful campus of the world-famous Buck Institute in Marin County, California.