Comprehensive Network Meta-Analysis on Blood Pressure Drug Discontinuation Rates

A network meta-analysis of 716 short-term randomized clinical trials found that discontinuation rates due to adverse events from blood pressure-lowering drugs varied substantially by class and combination.

Regimens containing angiotensin II receptor blockers (#ARBs), especially ARB plus calcium channel blocker (#CCB), were associated with fewer treatment discontinuations than placebo, while CCB monotherapy and certain combinations had higher discontinuation rates.

All drug regimens increased dizziness, but most reduced headache compared with placebo. Several combination therapies were better tolerated than monotherapies, providing important insights for antihypertensive regimen selection.

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